Anti-Bodies

Question 1

Rheumatoid Factor

Answer 1

RA
Primary Sjogrens
Quite sensitive for RA

Question 2

Anti-CCP

Answer 2

RA, very specific, mostly sensitive

Question 3

ANA

Answer 3

Very sensitive for SLE, not specific but good for ruling it out

Question 4

Anti-dsDNA

Answer 4

SLE very specific, but only positive in like 30%

Question 5

Anti-RNP

Answer 5

Mixed CTD

Question 6

Anti-centromere

Answer 6

Systemic sclerosis

Question 7

Anti-Scl-70

Answer 7

Diffuse systemic sclerosis

Question 8

Anti-Ro, Anti-La

Answer 8

Primary Sjogren’s syndrome

Can cause neonatal complete heart block (if this is detected the child needs a pacemaker for life)

Question 9

Anti-Jo-1

Answer 9

Idiopathic inflammatory myositis

Question 10

Anti-Sm

Answer 10

Very specific for SLE but only positive in like 3%

Question 11

Anti-cardiolipin

Answer 11

Associated with anti-phospholipid syndrome

Also associated with early pregnancy loss and clotting

Question 12

c-ANCA / anti-PR3

Answer 12

Quite specific to GPA

Question 13

p-ANCA / anti-MPO

Answer 13

Microscopic polyangiitis
eGPA
also not specific and may be raised in infection or IBD

Question 14

Which drugs may raise MCV?

Answer 14

Sulfasalazine
Methotrexate
Azathioprine

Question 15

What is the eosinophil count in Churg-Strauss?

Answer 15

High

this is eGPA