Anti Bacterial Antibiotics Flashcards
1
Q
What is the skeleton of Tetracyclines
A
Octa-hydro naphthacene
2
Q
Which is the first member of Tetracycline and what was it derived from?
A
First compound was chlorotetracycline and it was derived from a culture of streptomyces aureofaciens
3
Q
How many chiral carbons are there in Tetracycline?
A
6 (4, 4a, 5, 5a, 6, 12a)
4
Q
Which compound from Tetracycline is given parenterally?
A
Oxytetracycline
5
Q
What is the MOA of Tetracycline?
A
Specific inhibition of bacterial protein synthesis by binding to 30s ribosomes subunit and preventing the binding of amino acyl tRNA to the mRNA ribosome complex
6
Q
Conditions for which Tetracycline are used
A
Meningitis, septicemia, endocarditis
