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Pharma 3 > Anti Angina and Vasodilators > Flashcards

Anti Angina and Vasodilators Flashcards

1
Q

Nitroglycerin Effects

A

Vessels relaxation
Dec VR and Heart Size
Increase in Coronary flow (variant angina)

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2
Q

Nitroglycerin ROA

A

Sublingual- recommended for acute
Transdermal- prophylaxis
IV- acute coronary

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3
Q

Nitroglycerin Pharmacokinetics

A

High first pass effect- Nitrate free

High lipid solubility

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4
Q

Nitroglycerin Toxicity

A

OH
Tachycardia
Throbbing Headache
Synergistic effects with PDE5 inhibitors (Sildenafil)

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5
Q

Isosirbide dinitrate difference from NG

A

Longer duration of action

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6
Q

Isosorbide mononitrate use

A

Active metabolite of the dinitrate

PROPHYLAXIS of angina

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7
Q

Nitroglycerin MOA

A

NO release, activates guanylyl cyclase, inc cGMP

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8
Q

Nonselective Competitive Agonist at B adrenoreceptors

A

Propanolol

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9
Q

Propanolol uses

A

Prophylaxis of angina

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10
Q

Duration of oral Propanolol

A

4-6 hrs

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11
Q

Most common toxicity of Propanolol

A

Asthma
Acute heart failure
Sedation

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12
Q

Drugs can be taken together with Propanolol

A

Cardiac depressants

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13
Q

B1 Selective drugs having less risk for bronchospasm

A

Atenolol

Metoprolol

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14
Q

Anti angina drugs with AV BLOCK toxicity

A

Propanolol
Diltiazem
Verapamil

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15
Q

Non-selective L type Ca channel blockers in cardiac vessels

A

Verapamil

Diltiazem

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16
Q

Goal of anti angina drugs

A

Inc O2 supply and Dec O2 demand

17
Q

Nifedipine difference from other CCB

A

Less cardiac effects

18
Q

Verapamil Oral and IV duration

A

4-8 hrs

19
Q

Toxicity distinct to Verapamil

A

EDEMA

20
Q

Nifedipine ROA and duration

A

Oral, 4-6 hrs

21
Q

Toxicity: Baroreceptor complex tachycardia

A

Nifedipine

22
Q

Other dihydropyridines (eg Nimodipine) difference with Nifedipine

A

SLOWER onset but LONGER duration (12hrs)

23
Q

Inhibits late sodium current in the heart

A

Ranolazine

24
Q

Modifies fatty acid oxidation

A

Ranolazine

25
Q

Ranolazine ROA and duration

A

6-8 hrs Oral

26
Q

QT interval prolongation and Constipation

A

Ranolazine

27
Q

Increases Ranolazine duration and concentration

A

CYP3A inhibitors

Pharma 3 (3 decks)

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