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Clinical Pathology > Anemia 2 > Flashcards

Anemia 2 Flashcards

0
Q

Is size usually helpful when diagnosing non-regenerative anemia?
What is an exception to this?

A
  • No

- FeLV induced macrocytosis

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1
Q

Defective or decreased RBC production can be a result of what?

A

Non-responsive bone marrow

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2
Q

Is RBC morphology usually helpful when diagnosing non-regenerative anemia?

A

No

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3
Q

Can a biochemical profile be helpful in diagnosing non-regenerative anemia?
What is an example?

A
  • Yes

- Anemia of renal disease

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4
Q

Can a bone marrow aspirate be helpful in diagnosing non-regenerative anemia?

A

Yes

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5
Q

What is the term for decreased red cell production?

A

Hypoplasia

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6
Q

What is the term used for complete lack of red blood cell production?

A

Aplasia

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7
Q

With a generalized anemia due to bone marrow problems, what can be seen?

A

All cell lines are decreased.

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8
Q

What is another term for general marrow suppression?

A

Aplastic anemia

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9
Q

What are 3 possible causes of aplastic anemia?

A
  • Infectious agents (Ehrlichia, FeLV)
  • Immune-mediated destruction
  • Drugs and chemicals
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10
Q

What are 2 examples of types of drugs that can cause aplastic anemia?

A
  • Antineoplastic

- Immunosuppressive drugs

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11
Q

What is an example of a toxin that can cause aplastic anemia?

A

Solvents such as benzene.

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12
Q

Estrogen can cause aplastic anemia in what 2 species?

A
  • Dogs

- Ferrets

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13
Q

What are 4 conditions that can contribute to estrogen causing aplastic anemia?

A
  • Iatrogenic
  • Granulosa cell tumors
  • Sertoli cell tumors
  • Unspayed female ferrets
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14
Q

The mechanism thought to cause estrogen related aplastic anemia is mediated through what organ?

A

The thymus

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15
Q

Bone marrow suppression is preceded by what with aplastic anemia?

A

Initial thrombocytosis and neutrophilia

16
Q

What are 3 examples of infectious agents that can cause aplastic anemia?

A
  • FeLV
  • Ehrlichia
  • EIA (lentivirus)
17
Q

Antibodies are directed against stem cells in what type of anemia?

A

Immune-mediated aplastic anemia

18
Q

What are 3 examples of drugs that can induce immune-mediated aplastic anemia?

A
  • Trimethoprim-sulfadiazine
  • Cephalosporin
  • Phenobarbital in dogs
19
Q

Can immune-mediated aplastic anemia be idiopathic?

A

Yes

20
Q

Is “pure red cell aplasia” common or rare?

A

Rare

21
Q

What are 2 possible causes of erythroid aplasia?

A
  • Immune-mediated destruction of RBC precursors

- Feline leukemia virus

22
Q

What are 3 examples of intrinsic causes of erythroid hypoplasia?

A
  • Myelodysplasia
  • Leukemia
  • Immune-mediated destruction of erythroid precursors
23
Q

What are 3 examples of extrinsic causes of erythroid hypoplasia?

A
  • Chronic renal disease
  • Endocrine disorders
  • Inflammatory disease

Clinical Pathology (12 decks)

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