Alzheimer's Disease

Question 1

Alzheimer’s Disease is?

Answer 1

1. Form of Dementia
2. Progressive memory loss & cognitive decline
3. Decrease Acetylcholine due to neuritic plaques & tangles in brain tissue = altering NT signaling

MMSE < 24 OUT OF 30 = Memory disorder

Question 2

Donepezil (Aricept) moa

Answer 2

Cholinesterase inhibitor
reversibly & noncompetitively inhibit centrally active acetylcholinesterase, the enzyme responsible for hydrolysis of acetylcholine

Question 3

Donepzil dosage forms

Answer 3

Tablets
ODT

Question 4

Donepezil max dose

Answer 4

10 mg QD

Question 5

Memantine (Namenda) moa

Answer 5

NMDA receptor antagonist
allows sodium & calcium entry into the cell
Neuroprotective

Question 6

Memantine is approved for

Answer 6

Moderate to Severe

Question 7

Rivastigmine (Exelon)

Answer 7

Acetylcholinesterase inhibitor
GI Upset

Question 8

Acetylcholine precursors

Answer 8

Acetyl-L-Carnitine
A-phosphatidylserine

Question 9

Mild -Moderate Alzheimer treatment

Answer 9

Acetycholinesterase inhibitors
Donepezil
Rivastigmine (Exelon)
Galantamine

Question 10

Moderate to severe alzheimers

Answer 10

Acetylcholinesterase inhibitor + Memantine

Question 11

Memantine + Donepezil

Answer 11

Namzaric 5 mg PO QD

Titrate weekly to 10 mg BID

Question 12

Donepezil dose

Answer 12

5 mg QHS

Max 10 mg