Allergic Response

Question 1

exaggerated response to foreign substance

Answer 1

hypersensitivity

Question 2

exaggerated response to foreign substance due to specific IgE

Answer 2

allergy

Question 3

genetic tendency to develop classic allergic diseases - AD, AR, HF, asthma

involveds capacity to produce IgE in response to common environmental proteins

Answer 3

atopy

Question 4

Gel & Coombs Type I

Answer 4

Immediate Reaction
IgE mediated
Ex: allergic rhinitis, anaphylaxis

Question 5

Gel & Coombs Type II

Answer 5

Cytotoxic Reaction Ab-Cell Tissues
IgG and IgM directed against cell surface
Ex: blood transfusion reaction, autoimmune hemaltic anemia

Question 6

Gel & Coombs Type III

Answer 6

Immune complex reaction Ag-Ab
IgG, IgA, IgM directed against solble antigen from “immune complexes”
Complexes stuck in various places
Ex: arthus, serum sickness, vasculities

Question 7

contain chemicals that causes allergic Sx that we can feel, see and treat

Answer 7

mast cells (granules)

Question 8

the conditions we associate with true allergies are typically

Answer 8

Type I / IgE mediated reactions

Question 9

antigen that causes allergy

Answer 9

allergen

Question 10

Mast cell mediators

Answer 10

histamine
leukotriene
cytokines (inflammation)
chemotactic agents
enzymes

Question 11

Why do we have IgE?

Answer 11

Parasites too big for phagocytes
IgE attaches to parasite and mast cell
Mast cell releases mediators to kill parasite