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Molecular Bio > Allen review slides > Flashcards

Allen review slides Flashcards

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Biology 101 flashcards
1
Q

an immune reaction against self. can be organ specific or widespread

A

Autoimmune Disease

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2
Q

Rheumatoid Arthritis, lupus, MS, Diabetes (pancreas), Graves Disease (thyroid) are examples of

A

Autoimmune diseases

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3
Q

the class of an antibody molecule is determined solely by its

A

heavy chain

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4
Q

antibodies have _____ numbers of large (heavy) and small (light) peptide chains

A

equal numbers

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5
Q

antibodies have _______ identical antigen binding sites

A

multiple

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6
Q

humanization of antibodies _______ immunogenicity

A

reduces

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7
Q

murine: % human and suffix

A

0% human, -omab

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8
Q

chimeric: % human and suffix

A

65% human, -ximab

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9
Q

humanized: % human and suffix

A

> 90% human, -zumab

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10
Q

fully human: % human and suffix

A

100% human, -umab

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11
Q

new capillary blood vessel growth in the body. natural process for healing and reproduction

A

angiogenesis

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12
Q

what is angiogenesis

A

new capillary blood vessel growth in the body

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13
Q

humanized antibody used in caner. targets programmed cell death receptor 1

A

pembrolizumab (Keytruda)

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14
Q

target of pembrolizumab (Keytruda)

A

programmed cell death receptor 1

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15
Q

autologous cellular immunotherapy designed to induce immune response against PAP (antigen in prostate cancers)

A

sipuleucel-T (Provenge)

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16
Q

target of sipuleucel-T (Provenge)

A

PAP (antigen in prostate cancers)

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17
Q

humanized monoclonal antibody that binds to HER2 gene and prevents dimerization and induces apoptosis through ADCC

A

Herceptin

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18
Q

target of Herceptin

A

HER2

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19
Q

recombinant chimeric mAb used in head and neck and colorectal cancer. prevents dimerization of EGFR

A

cetuximab (Erbitux)

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20
Q

target of cetuximab (Erbitux)

A

EGFR

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21
Q

Regorafenib inhibits ______

A

angiogenesis

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22
Q

what drug inhibits angiogenesis

A

Regorafenib (Stivarga)

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23
Q

anti-IL5 therapy used for asthma

A

Mepolizumab

24
Q

what are anti-IL5 therapies used for

A

asthma

25
Q

difference in infliximab and adalimumab

A

infliximab=chimeric, adalimumab=human

26
Q

is infliximab or adalimumab chimeric

A

infliximab

27
Q

mAb are currently used to reduce __________ associated with __________ __________

A

inflammation, Rheumatoid arthritis

28
Q

are men or women more likely to develop RA

A

women

29
Q

undesirable immune reaction produced by normal immune system. immune response is exaggerated

A

hypersensitivity

30
Q

how many types of hypersensitivity reactions are there

A

4

31
Q

antibody mediated hypersensitivities

A

type 1, 2, 3

32
Q

cell mediated hypersensitivity

A

type 4

33
Q

are T or B cells responsible for CELL-mediated immunity

A

T-cells

34
Q

are T or B cells responsible for producing antibodies

A

B cells

35
Q

Classic Allergy

A

Type 1 Hypersensitivity

36
Q

symptoms resulting from allergic responses are known as

A

anaphylaxis

37
Q

what is used to diagnose allergies

A

skin test

38
Q

is type 1 hypersensitivity immediate or delayed

A

immediate

39
Q

examples of type1 hypersensitivity

A

hay fever, asthma, eczema, bee stings, food allergies

40
Q

hay fever, asthma, eczema, bee stings, food allergies

A

type 1 hypersensitivity

41
Q

IgG mediated-Cytotoxic Hypersensitivity

A

Type 2 hypersensitivity

42
Q

utilizes antibodies that can destroy normal cells by lysis or ADCC

A

type 2 hypersensitivity

43
Q

blood transfusion reaction

A

type 2 hypersensitivity

44
Q

ex of type 2 hypersensitivity

A

blood transfusion reactions

45
Q

immune complex mediated hypersensitivity/”Frustrated Phagocytes”

A

type 3 hypersensitivity

46
Q

slight excess of antigen, antigen-Ab complex activated complement and stimulates neutrophil and basophil degranulation

A

type 3 hypersensitivtiy

47
Q

is type 4 hypersensitivity delayed or immediate

A

delayed

48
Q

ex of type 4 hypersensitivity

A

positive Tb test, poison ivy, Multiple sclerosis

49
Q

positive Tb test, poison ivy, Multiple sclerosis

A

type 4 hypersensitivity

50
Q

Th1 and Th17 act against myelin —> demyelination in CNS

A

multiple sclerosis

51
Q

IgE mediated hypersensitivity

A

type 1 hypersensitivity

52
Q

administration of antiserum containing preformed antibodies. gives immediate protection against recent infection or ongoing disease

A

passive immunotherapy

artificial passive immunity

53
Q

2 examples of antiserums that yield passive immmunity

A

rabies vaccine, snake antivenom

54
Q

antibodies created within a different person or animal

A

antiserum

55
Q

an immediate hypersensitive reaction develops in less than ___ hours

A

24 hours

56
Q

a delayed hypersensitivity reaction develops in ____-____ hours

A

24-48 hours

Molecular Bio (3 decks)

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