Alcohol Metabolism

Question 1

what is alcohol made into in the liver?

Answer 1

acetaldehyde

Question 2

where is liver is alcohol converted into acetaldehyde?

Answer 2

cytoplassm

Question 3

where is liver is acetaldehyde converted into acetate?

Answer 3

mitochondria

Question 4

name the three alcohol degrdation pathways?

Answer 4

catalase
P4502E1
ADH

Question 5

what pathway uses alcohol dehydrogenase?

Answer 5

ADH

Question 6

what is the cofactor for the ADH/alcdehydrogenase path?

Answer 6

NAD+ into NADH

Question 7

what is another name for the P4502E1 pathway?

Answer 7

microsomal ethanol oxidizing system

Question 8

what is the cofactor in the P4502E1?

Answer 8

NADPH into NADP+

Question 9

where does alcohol dehydrogenase act?

Answer 9

mainly liver but can work in stomach kidney and lung

Question 10

what pathway handles low levels of alcohol?

Answer 10

ADH

Question 11

what pathway kicks in for high levels of alcohol?

Answer 11

MEOS (P4502E1)`

Question 12

why is P4502E1 active at high conc?

Answer 12

because it has a large Km meaning it has a low affinity

Question 13

where does catalase turn alc into acetaldehyde?

Answer 13

peroxisomes

Question 14

what is cofactor for peroxisome catalase?

Answer 14

H2O2 `

Question 15

what is alcohol product that causes hangover?

Answer 15

acetaldehyde

Question 16

what are the two forms of acetaldheyde dehydrogenase that converts acetaldehyde into acetate?

Answer 16

ALDH2.1

ALDH2.2

Question 17

which ALDH is quick at converting

Answer 17

ALDH2.1

Question 18

which ALDH is slow at converting

Answer 18

ALDH2.2

Question 19

what is issue with ALDH2.2 being slow at converting acetaldehyde into acetate?

Answer 19

worse hangovers…drinking deterrent

Question 20

because of the liver breakdown of alcohol, what builds up in the liver that can be harmful? hint it is a cofactor result

Answer 20

NADH