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CAR-T Therapies > AI Generated > Flashcards

AI Generated Flashcards

1
Q

What does CAR-T stand for?

A

Chimeric Antigen Receptor T-cell

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2
Q

True or False: CAR-T therapies involve genetically modifying a patient’s T-cells to attack cancer cells.

A

True

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3
Q

Which type of cancer has the first FDA-approved CAR-T therapy been used to treat?

A

Acute lymphoblastic leukemia (ALL)

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4
Q

What is the name of the first FDA-approved CAR-T therapy?

A

Kymriah

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5
Q

What is the primary advantage of CAR-T therapy over traditional cancer treatments?

A

Specific targeting of cancer cells

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6
Q

What is the potential downside of CAR-T therapy?

A

Cytokine release syndrome

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7
Q

Which company developed the CAR-T therapy Yescarta?

A

Gilead Sciences

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8
Q

True or False: CAR-T therapy is a type of immunotherapy.

A

True

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9
Q

What is the general process of CAR-T therapy?

A

Collecting T-cells, modifying them in a lab, and reinfusing them into the patient

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10
Q

What is the main challenge in developing CAR-T therapies?

A

Managing side effects and ensuring long-term effectiveness

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11
Q

What is the name of the CAR-T therapy approved for the treatment of diffuse large B-cell lymphoma?

A

Yescarta

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12
Q

What is the role of the chimeric antigen receptor in CAR-T therapy?

A

It allows T-cells to recognize and target cancer cells

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13
Q

True or False: CAR-T therapy has shown promising results in treating solid tumors.

A

False

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14
Q

Which type of cancer is being targeted in ongoing CAR-T therapy clinical trials?

A

Multiple myeloma

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15
Q

What is the main goal of CAR-T therapy in cancer treatment?

A

To eliminate cancer cells while sparing healthy cells

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16
Q

What is the main limitation of CAR-T therapy?

A

High cost

17
Q

Which step in the CAR-T therapy process involves the use of a viral vector to introduce the chimeric antigen receptor gene into T-cells?

A

Transduction

18
Q

What is the significance of the CAR-T therapy trial results in terms of patient outcomes?

A

Significant improvement in survival rates

19
Q

True or False: CAR-T therapy is currently only approved for use in children with cancer.

A

False

20
Q

What is the main reason why CAR-T therapy may not be suitable for all cancer patients?

A

Potential severe side effects

21
Q

What is the primary mechanism of action of CAR-T therapy in targeting cancer cells?

A

Recognition of specific antigens on cancer cells

22
Q

Which regulatory agency approved the first CAR-T therapy for commercial use?

A

FDA (Food and Drug Administration)

23
Q

True or False: CAR-T therapy requires a patient’s immune system to be functioning normally.

A

True

24
Q

What is the main reason why CAR-T therapy is considered a personalized treatment approach?

A

It involves modifying the patient’s own immune cells

CAR-T Therapies (3 decks)

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