AI Generated Flashcards
What does CAR-T stand for?
Chimeric Antigen Receptor T-cell
True or False: CAR-T therapies involve genetically modifying a patient’s T-cells to attack cancer cells.
True
Which type of cancer has the first FDA-approved CAR-T therapy been used to treat?
Acute lymphoblastic leukemia (ALL)
What is the name of the first FDA-approved CAR-T therapy?
Kymriah
What is the primary advantage of CAR-T therapy over traditional cancer treatments?
Specific targeting of cancer cells
What is the potential downside of CAR-T therapy?
Cytokine release syndrome
Which company developed the CAR-T therapy Yescarta?
Gilead Sciences
True or False: CAR-T therapy is a type of immunotherapy.
True
What is the general process of CAR-T therapy?
Collecting T-cells, modifying them in a lab, and reinfusing them into the patient
What is the main challenge in developing CAR-T therapies?
Managing side effects and ensuring long-term effectiveness
What is the name of the CAR-T therapy approved for the treatment of diffuse large B-cell lymphoma?
Yescarta
What is the role of the chimeric antigen receptor in CAR-T therapy?
It allows T-cells to recognize and target cancer cells
True or False: CAR-T therapy has shown promising results in treating solid tumors.
False
Which type of cancer is being targeted in ongoing CAR-T therapy clinical trials?
Multiple myeloma
What is the main goal of CAR-T therapy in cancer treatment?
To eliminate cancer cells while sparing healthy cells
What is the main limitation of CAR-T therapy?
High cost
Which step in the CAR-T therapy process involves the use of a viral vector to introduce the chimeric antigen receptor gene into T-cells?
Transduction
What is the significance of the CAR-T therapy trial results in terms of patient outcomes?
Significant improvement in survival rates
True or False: CAR-T therapy is currently only approved for use in children with cancer.
False
What is the main reason why CAR-T therapy may not be suitable for all cancer patients?
Potential severe side effects
What is the primary mechanism of action of CAR-T therapy in targeting cancer cells?
Recognition of specific antigens on cancer cells
Which regulatory agency approved the first CAR-T therapy for commercial use?
FDA (Food and Drug Administration)
True or False: CAR-T therapy requires a patient’s immune system to be functioning normally.
True
What is the main reason why CAR-T therapy is considered a personalized treatment approach?
It involves modifying the patient’s own immune cells
