ADVANTAGES OG FIXED RATIO BASAL GLP1A

Question 1

What condition does the patient have?

Answer 1

Macrovascular disease with recent transient ischemic attack and poor peripheral pulses due to ongoing smoking

Question 2

Which medications are GLP-1 receptor agonists mentioned?

Answer 2

Semaglutide, dulaglutide

Question 3

What is the effect of GLP-1 receptor agonists when combined with metformin?

Answer 3

Reduce cardiovascular event risk

Question 4

What specific benefit does semaglutide provide in secondary outcomes?

Answer 4

Reduced stroke risk

Question 5

How does hyperglycemia affect stroke risk?

Answer 5

Increases stroke risk

Question 6

What type of agents are needed to address hyperglycemia?

Answer 6

Potent glucose-lowering agents

Question 7

What is the nausea risk for basal insulin/GLP-1 receptor agonist fixed-ratio coformulations compared to GLP-1 agonists alone?

Answer 7

Lower nausea risk

Question 8

What are the nausea rates for insulin degludec/liraglutide?

Answer 8

8-9%

Question 9

What are the nausea rates for insulin glargine/lixisenatide?

Answer 9

10%

Question 10

What are the nausea rates for dulaglutide alone?

Answer 10

20-30%

Question 11

What should be considered if a patient is unable to tolerate GLP-1 agonists?

Answer 11

Insulin glargine

Question 12

What is the effect of pioglitazone on stroke risk?

Answer 12

Reduces stroke risk

Question 13

What is a limitation of pioglitazone in managing blood sugar levels?

Answer 13

Takes time and may not sufficiently lower HbA1c