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V - KCU - HDM {T1} - OMS1 > Adaptive Antigen Recognition In The Immune System (Ch. 4) > Flashcards

Adaptive Antigen Recognition In The Immune System (Ch. 4) Flashcards

1
Q

Each lymphocyte clone is specific for what

A

A distinct Ag and a unique receptor

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2
Q

B-cells recognize the ______ of protein, lipid, carb, and NA Ag?

A

Shape

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3
Q

What are the two regions of Ag receptor domains

A

Variable and constant

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4
Q

What are the Ag receptors for B-cells and T-cells called

A

BCR and TCR

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5
Q

What are the two functions of Ag receptors

A
  1. Specific Ag recognition

2. Signal transduction

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6
Q

How does TCR and BCR work on intracellular pathways

A

Phosphorylates them

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7
Q

Secreted Ab (Ig) are part of what type of immunity

A

Humoral (adaptive) immunity

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8
Q

Ig recognize Ag by what

A

Their variable group

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9
Q

What are the 4 parts of a Ig

A

2 identical Heavy chains
2 identical Light Chains

Each with a V and C group(s)

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10
Q

LC has how many V and C

A

1 v and 1 c

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11
Q

HC has how many V and C

A

1v and 3-4 C

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12
Q

The Ag binding regions of Ig has what type of cells

A

Variable

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13
Q

Which CDR has the highest binding affinity for Ag

A

CDR 3 (most variable)

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14
Q

Define the FAB

A

Fragment Ag Binding domain

Contains the VL - VH and first CL - CH

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15
Q

What does the FAB and FC do respectively

A

FAB - binds to Ag

FC - responsible for the effector function

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16
Q

How do the HC differ from eachother

A

Differ in C regions

17
Q

What are the functions of IgA

A

Mucosal immunity

18
Q

What are the functions of IgD

A

Naive B-cell Ag receptor

19
Q

What are the functions of IgE

A

Defense against helminthic parasites

20
Q

What are the functions of IgG

A

Activate opsonization

Also feedback inhibition of B cells

21
Q

What are the functions of IgM

A

naive B cell Ag receptor

22
Q

What are the two types of LC and what are their functions

A

K and Lamda

Differ in C regions, B-Cells express one or the other, but not both

23
Q

Define the bond between Ab and Ag

A

Reversible with H-Bonds

24
Q

What are the two types of epitopes that Ig’s can recognize

A
  1. Linear - (sequence of AA)

2. Conformational - shape

25
Q

Decreased Kd means what

A

Increased affinity

26
Q

IgG, IgD, and IgE have how many binding sites

27
Q

How many binding sites does IgA have

A

4 (because it is a dimer)

28
Q

How many binding sites does IgM have

29
Q

TCR has what domains

A

A single A and B chain

30
Q

TCR also requires attachment of what

A

Co-factors CD4 or CD8

V - KCU - HDM {T1} - OMS1 (5 decks)

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