Adaptive Antigen Recognition In The Immune System (Ch. 4)

Question 1

Each lymphocyte clone is specific for what

Answer 1

A distinct Ag and a unique receptor

Question 2

B-cells recognize the ______ of protein, lipid, carb, and NA Ag?

Answer 2

Shape

Question 3

What are the two regions of Ag receptor domains

Answer 3

Variable and constant

Question 4

What are the Ag receptors for B-cells and T-cells called

Answer 4

BCR and TCR

Question 5

What are the two functions of Ag receptors

Answer 5

1. Specific Ag recognition

2. Signal transduction

Question 6

How does TCR and BCR work on intracellular pathways

Answer 6

Phosphorylates them

Question 7

Secreted Ab (Ig) are part of what type of immunity

Answer 7

Humoral (adaptive) immunity

Question 8

Ig recognize Ag by what

Answer 8

Their variable group

Question 9

What are the 4 parts of a Ig

Answer 9

2 identical Heavy chains
2 identical Light Chains

Each with a V and C group(s)

Question 10

LC has how many V and C

Answer 10

1 v and 1 c

Question 11

HC has how many V and C

Answer 11

1v and 3-4 C

Question 12

The Ag binding regions of Ig has what type of cells

Answer 12

Variable

Question 13

Which CDR has the highest binding affinity for Ag

Answer 13

CDR 3 (most variable)

Question 14

Define the FAB

Answer 14

Fragment Ag Binding domain

Contains the VL - VH and first CL - CH

Question 15

What does the FAB and FC do respectively

Answer 15

FAB - binds to Ag

FC - responsible for the effector function

Question 16

How do the HC differ from eachother

Answer 16

Differ in C regions

Question 17

What are the functions of IgA

Answer 17

Mucosal immunity

Question 18

What are the functions of IgD

Answer 18

Naive B-cell Ag receptor

Question 19

What are the functions of IgE

Answer 19

Defense against helminthic parasites

Question 20

What are the functions of IgG

Answer 20

Activate opsonization

Also feedback inhibition of B cells

Question 21

What are the functions of IgM

Answer 21

naive B cell Ag receptor

Question 22

What are the two types of LC and what are their functions

Answer 22

K and Lamda

Differ in C regions, B-Cells express one or the other, but not both

Question 23

Define the bond between Ab and Ag

Answer 23

Reversible with H-Bonds

Question 24

What are the two types of epitopes that Ig’s can recognize

Answer 24

1. Linear - (sequence of AA)

2. Conformational - shape

Question 25

Decreased Kd means what

Answer 25

Increased affinity

Question 26

IgG, IgD, and IgE have how many binding sites

Answer 26

2

Question 27

How many binding sites does IgA have

Answer 27

4 (because it is a dimer)

Question 28

How many binding sites does IgM have

Answer 28

10

Question 29

TCR has what domains

Answer 29

A single A and B chain

Question 30

TCR also requires attachment of what

Answer 30

Co-factors CD4 or CD8