Acute Lymphoblastic Leukemia - Krafts Flashcards
1
Q
Acute Lymphoblastic Leukemia:
Things you must know!
A
- Malignant proliferation of lymphoid blasts in blood, bone marrow
- Classified by immunophenotype (B vs. T)
- More common in children
- Prognosis often good!
2
Q
ALL Classification:
Both have what?
A
Both: TdT
T cell Ag in the T type
B cell Ag in B type :)
3
Q
B or T has worse prognosis?
A
T lymphoblastic leukemia
4
Q
T-lymphoblastic Leukemia
Things you much know!
A
==T lymphoblastic lymphoma
Teenage male with mediastinal mass is typical pt
WBC usually really high with 2 kinds of blast cells
BAD prognosis :(
5
Q
B Lymphoblastic Leukemia
Things you must know!
A
=== B-cell lymphoblastic lymphoma
- Several sub- and sub-subtypes
- TdT +
Rarely, Ph + ! (Philadelphia chromosome)
6
Q
Acute Lymphoblastic Leukemia most common in?
A
CHILDREN!
7
Q
ALL:
Prognosis—>
Treatment—>
A
Prog:
- -Immunophenotype (T is bad)
- -Age (1-10 good)
- -WBC (lower is better,
