abnormal puberty

Question 1

what are the hormones associated with puberty

Answer 1

pulsatile GnRH relesase stimulates FSH adn LH release. LH causes sex hormone production by the gonads

Question 2

when does puberty begin

Answer 2

males
14-15yrs
late growth spurt
testicle enlargement - pubic hair - growth spurt

females
13-24
early growth spurt
boobs - pubes - grow - flow

Question 3

what is the defintiion of delayed puberty

Answer 3

males onset >14-15yrs

females onset >13-14yrs menarche >16yrs

Question 4

what are the types of delayed puberty

Answer 4

normal/decreased LH/FSH

• constitutional delay (most common, often familial, short stature, delayed bone age)
• chronic illness (CF, AN)
• endocrine (hypopituitrism, hyperprolactinaemia)

increased LH/FSH
- primary gonadal failure
(Turners, Klinefelters, chemo, irradiation)

Question 5

what is the definition of precocious puberty

Answer 5

females onset <8yrs
males onset <9yrs
more common in girls than boys, less likely to be pathological in girls

Question 6

what are the types of precocious puberty

Answer 6

gonadotropin dependent/true

• idiopathic
• intracranial pathology/tu
• hypothalamic hamartoma (no neuro sx)

gonadotropin independent

• CAH
• McCune Albright syndrome
• ovarian/test/adrenal tu