9.1 pain lecture Flashcards
afferents that respond to damaging or potentially damaging stimuli
nociceptive afferents
size of nociceptive afferents
small diameter
are nociceptive afferents myelinated?
no
chemicals released after nociceptor activation
histamine, kinins, prostaglandins
action of released chemicals
sensitizee nociceptors, produce swelling and redness
these are released from nociceptive nerve endings
pro-inflammatory peptides
name for sensitization of nociceptors in region of injury
hyperalgesia
pain perception can be enhanced or diminished by what interaction?
noxious and innocuous (tactile) sensory inputs
where nociceptive afferents enter the spinal cord
dorsal
nociceptive afferents synapse here
superficial layers (laminae I and II) of grey matter, also layer V
projection neurons of laminae I and V project across _____ and ascend to the brain in the _________
the spinal cord and the anteriolateral tract. also called the spinothalamic tract
structures that are involved with the localisation of but not the affective experience of pain
somatosensory cortex and dorsal column pathway
two cortexes that elaborate the conscious experience of pain
cingulate and insular cortex
how visceral pain is referred to a cutaneous site
visceral nociceptive afferents synapse with neurons transmitting somatic nociceptive information - forms a somatotopic representation
the name for pain experienced without activation of nociceptors
neurogenic or neuropathic pain
the first synapse for nociceptive information
between the primary sensory fibre and the dorsal horn neuron
neurons in dorsal horn of spinal cord exhibit what changes?
short and long term changes in excitability
descending projection from peri-aquaductal grey in midbrain to what
dorsal horn - decreases ascending neurotransmission via opiod neurotransmitters
