65 Flashcards
What is unusual about the VZV compared to all other herpesvirus’s?
Most primary infections have S&S
Causative agent of chickenpox
Varicella-Zoster Virus
- herpesvirus
- dsDNA
- Rep in nucleus
S&S of chickenpox
Assymetrical vesicular rash following dermatomal patter Pruritis lesions (often inf. with bactera)
Stages of chickenpox
2 waves of viremia
1) Rep in regional lymph node & causes viremia 4-6days post infection
2) Rep in liver/spleen & cause viremia 10-14 post infection & cause rash
Most common childhood exanthum in US
Chickenpox
Communicability of chickenpox
highly contagious via resp. droplets
-1-2 days before rash and 4-5 days after
Prodrome seen in chickenpox?
Only in older children
-fever, malaise, HA
TRX of chickenpox
Symptomatic
-no aspirin (also none for 28 days post vaccine)
VariZIG
-immunoglobin or high risk up to 4 days post exposure
Chickenpox vaccine info
Varivax - live attenuated
-12-18mo
adults/teens get 2 injections
CI:preg
Complications of varivax
Shingles (risk lower than from natural inf)
Mild post infection
Breakthrough Varicella
-2 doses reduces risk
Complications of chickenpox
GAS b hemolytic infection of lesions
Population most commonly with shingles
Adults
Cause of Shingles
Reactivation of latent VZV, must have hx of chickenpox
S&S of shingles
PAINFUL Rash (pain may precede rash) Unilateral and dermatomal vesicular rash that does not cross midline
10% of pt with shingles have ______ involv.
20% of pt with shingles have ______ involv.
- ophthalmic branch of CN5
- ocular nerves
