64.glomerulonephritis with nephritic syndrome Flashcards
what are the types of acute diffuse proliferative GN
1.post-strept
2.non- strept
when does post-strepto GN occur?
10-14d after upper respiratory infection with nephritic strains of beta hemolytic streptococcus
-results from immune complexes of streptococcal Ag and AB
post-strepto GN occurs mostly in
children
symptoms of post-strept GN
1.proteinuria
2.hematuria
3.hypoalbuminemia
4.hypertension
post-strept GN may progress to
renal failure
-may evolve
—slow as chronic GN
—fast as rapidly progressive GN
describe the histological changes in post-strept GN
1.inflammation of glomeruli - diffuse and global
2.all capillaries are involved
3.glomeruli are enlarged and hypercellular, due to proliferation of mesangial cells and presence of inflammatory infiltrate consisting of neutrophils and macrofages
4.immune complexes found in bm and mesangial areas
which type of acute diffuse proliferative GN has the better prognosis
post-streptococcal
acute non-strept GN can be caused by
- staphylococci
- meningococci
- salmonella
- hepatitis B
- malaria
which are the etiologies for rapidly progressive GN
1.streptococci
2. lupus
3. vasculitis
4. idiopathic
symptoms of rapidly progressive GN
1.nephritis
2.oliguria/anuria
histological findings in rapidly progressive GN
1.crescent formations in glomeruli
—circumferential proliferation of epithelial cells and monocytes in Bowmans space due to leaked fibrin from damaged capillary loops
treatment of rapidly progressive GN
immunosuppression
definition of goodpasture syndrom
autoimmune disorder, where autoantibodies form against collagen type 4 of glomerular and pulmonary capillary bm
goodpasture syndrome in kidneys begins as … and progresses into..
begins as focal and segmental necrotizing GN
and progresses into crescent GN
who is more prone to goodpasture syndrome
males around 20-30yrs
