5-HT1a receptor agonists Flashcards
1
Q
Dose
A
1 tablet ASAP
2nd tablet at least 2 hours later (4 hours if naratriptan) if migraine recurs
- Do not take a second dose for same attack.
1
Q
MoA
A
Acts on 5-HT1d and 5-HT1b receptors present on cranial arteries/veins to cause vasoconstriction
2
Q
Side effects
A
Common = dizziness, drowsiness, dyspnoea, N +V, flushing
Coronary vasoconstriction
Anaphylaxis
3
Q
CI
A
- Ischaemic heart disease
- Previous MI
- Uncontrolled or moderate-severe hypertension
- Peripheral vascular disease
- Previous stroke/TIA
- Coronary vasospasm
- Prinzmetals angina
4
Q
Counselling
A
Stop if intense tingling, heat, heaviness, pressure or tightness in the body
5
Q
Interactions - risk of serotonin syndrome
A
SSRI
TCAs
MAOIs
Tramadol
6
Q
Examples
A
Sumatriptan (choice)
Zolmitriptan (can also treat cluster)
