2nd/3rd adrenal insufficiency

Question 1

describe the pathophysiology in secondary adrenal insufficiency?

Answer 1

1. low ACTH
2. adrenal gland function is not affected, it is only not stimulated
3. • hypoandrogenism
   • hypocortisolism

Question 2

describe the pathophysiology in tertiary adrenal insufficiency?

Answer 2

1. decresed CRH production
2. decreased ACTH
3. hypoandrogenism and hypocortisolism

Question 3

why is aldosterone secretion normal?

Answer 3

1. adrenal gland is functioning normally
2. aldosterone is regulated by the RAAS
3. thus independant of hypothalamus and pituitary

Question 4

Clinical features

Answer 4

1. Symptoms of hypocortisolism
2. symptoms of androgenism alone
3. NO ELEVATE ACTH/HYPOALDOST

Question 5

Mx

Answer 5

glucocorticoid replacement

- hydrocortisone