29 Flashcards
How does it work when an odourant binds to a receptor?
An odorant binds to a receptor and produces G protein. It then travels to an enzyme, Adenylyl cyclase, with, using ATP, releases cAMP and mediates a sodium ion Chanel from the outside to the inside of the cell. Your brain then perceives the signal.
Transient Receptor Potential cation channel (TRPC2)?
A gene is expressed only in the vomeronasal organ.
TRPC2 mutations does what?
Mutations inactivate ion channels. It specifically affect the V2R receptor family.
Egr1 gene is expressed only?
pheromone exposure only in the VNO.
!!!!Process when pheromone binds with V2R?
Pheromone binds with V2R. G protein undergoes
VNO receptors are or are not species-specific responses
They are
Knocking out TRPC2 blocks?
Blocks pheromone perception since the signal cannot travel do the brain by stopping the function of the sodium ion channel.
Heterozygous individuals, functional and non functional TRPC2 act or does not act the same as the wild type, two functional TRPC2?
Heterozygous individuals, functional and non functional TRPC2 act the same as the wild type.
Male-male TRPC2 mutant mice tries to do what?
Mate with each other since they cannot sense the sex of the opposing mouse.
TRPC2 mutants?
Inactivated TRPC2
Female-male TRPC2 mutant mice tries to do what?
Female mice are likely to mount female and male mice similarly, and vice versa. Similar for mating.
Do humans have functional TRPC2 genes?
No
Vomeronasal organ response to?
High molecular weight fraction (HMW).
The major olfactory epithelium in mice response to?
low molecular weight fraction (LMW).
Major Urine Protein (MUP) and V2R’s are found only in?
Rodents and marsupials
