20 - Natural disease & Forensic Path Flashcards
1
Q
2 major types of autopsies
A
- Coronial
- Consent (hospital) autopsy
2
Q
Cardiac causes of death
A
Coronary artery causes and non coronary causes
3
Q
Coronary causes
A
- Atherosclerosis
- Dissection
- Vasculitis
4
Q
Non coronary causes
A
- Hypertensive heart disease
- Valve disease
- Myocarditis
5
Q
Dissection
A
Blood outside the lumen
6
Q
Vasculitis
A
Inflammation of the blood vessels
7
Q
Myocarditis
A
- Heals with scarring
- Leads to dilated cardiomyopathy
- Usually viral (coxsackie A or B)
- Lymphocytic
- Eosinophilic (hypersensitivity)
- Gaint cell (idiopathic, poor prognosis)
8
Q
Hypertrophic cardiomyopathies
A
- Most common cause of sudden cardiac death in young
- Diastolic dysfunction
- LV outflow obstruction
- Heterogenous
- Asymmetric
- Fibrous plaque on septum
- Myofibre disarray
9
Q
Dilated cardiomyopathies
A
- 4 chamber dilation
- Cardiomegaly, interstitial fibrosis
- Systolic dysfunction
10
Q
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
A
- Fibrofatty replacement and inflammation of RV (usually)
- RV dysfunction and arrhythmias
- May invlove LV
- Familial (multiple genes)
11
Q
Restrictive cardiomyopathies
A
Amyloid, radiation-induced fibrosis
12
Q
Hypertensive heart disease
A
- Cardiomegaly
- Concentric LV hypertrophy
- Myocardial fibrosis
- Myocyte hypertrophy
13
Q
Valvular heart disease
A
- Floppy mitral valve/MV prolapse
- Aortic stenosis
- Infective endocarditis
14
Q
Floppy mitral valve/MV prolapse
A
Cause of sudden death
15
Q
Aortic stenosis
A
Sudden death due to massive cardiomegaly
