1.8 - Genomic sequencing Flashcards

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1
Q

in genomic sequencing the ………. can be determined for ………. or ……….

A

sequence of nucleotide bases, individual genes, entire genomes

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2
Q

computer programs can be used to identify…

A

base sequences by looking for sequences similar to known genes

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3
Q

what are the types of bioinformatics

A

computers and statistical analysis

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4
Q

what is used to compare sequence data

A

bioinformatics

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5
Q

what has comparison of genomes revealed

A

many genes are highly conserved across different organisms

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6
Q

what genomes have been sequenced in particular?

A

disease-causing organisms, pest species and species that are important models organisms for research

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7
Q

what is phylogenetics

A

the study of evolutionary history and relationships

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8
Q

in phylogenetics, what can sequence data be used for (2 examples)

A

to determine the main sequence of events in evolution to study the evolutionary relatedness among groups of organisms

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9
Q

what is sequence divergence used for

A

to estimate time since lineages diverged

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10
Q

what provides evidence of the three domains of life

A

comparison of sequences

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11
Q

what are the 3 domains of life

A

bacteria, archaea eukaryotes

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12
Q

what is used to determine the main sequence of events in evolution

A

sequence data and fossil evidence

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13
Q

what is the sequence of events in evolution

A

CLPPEMAVL

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14
Q

what is used to show when species diverged during evolution

A

molecular clocks

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15
Q

what do molecular clocks assume

A

constant mutation rate

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16
Q

molecular clocks show what differences

A

changes in DNA sequences or amino acid sequences

17
Q

what can an individuals genome be analysed to predict

A

the likelihood of developing certain diseases

18
Q

what is pharmacogenetics

A

the use of genome information in the choice of drugs

19
Q

what can an individuals personal genome sequence be used to select

A

the most effective drug and dosage (personalised medicine)