1.3.3 Treatment and management of impulse control disorders Flashcards
Biological treatments
Opiod antagonists
Opiates are a group of powerful drugs used as painkillers, they are considered high-risk, e.g. heroin is one of them.
Biological treatments
What has been used to treat ICDs, with the least success with gambling disorder?
SSRIs.
Biological treatments
What does some research suggest opiate antagonists may be successful in treating?
Gambling disorders.
GRANT ET AL. (2008)
What do endorphins bind to?
What does this allow?
Endorphins bind to opioid receptors, inhibit GABA and allow dopamine to increase.
GRANT ET AL. (2008)
What do opioid antagonists do?
Block opioid receptors and reduce euphoria.
GRANT ET AL. (2008)
What does a lack of reinforcement (euphoria) lead to?
The extinction of compulsive behaviours.
GRANT ET AL. (2008)
Aim & hypothesis
To investigate opiate antagonists as a treatment for gambling disorder.
Opiate antagonists are more effective in reducing gambling disorder in people with a family history of alcoholism, strong urges and euphoric response to alcohol compared to people who do not fit into these categories.
GRANT ET AL. (2008)
Method
Experiment/randomised control trials, independent measures, double-blind.
GRANT ET AL. (2008)
Participants
- 284 pathological gamblers.
- Had all gambled in the past 2 weeks.
- Outpatients from 15 psychiatric centres.
- Equal no. of males/females
- From the USA.
GRANT ET AL. (2008)
What conditions were ppts assigned to?
Low, moderate or high dose of nalmefene, naltrexone or placebo.
GRANT ET AL. (2008)
What technique was used to assign ppts to their condition?
Random allocation.
GRANT ET AL. (2008)
How many trials took place?
What style were they?
How long did they last?
2 double-blind placebo clinical trials which lasted either 16 or 18 weeks.
GRANT ET AL. (2008)
How did Grant measure the severity of ppts’ gambling?
Yale-Brown obsessive compulsive scale modified for pathological gambling (PG-YBOCS).
GRANT ET AL. (2008)
Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling (PG-YBOCS)
A clinician-administered scale to assess gambling severity by assessing symptoms over the previous 7 days, in terms of both gambling urges/thoughts and gambling behaviour.
GRANT ET AL. (2008)
Apart from using the PG-YBOCS, how was data gained from ppts?
What was the data about?
Semi-structured interviews were used to gather family history, particularly relating to first-degree relatives with alcoholism.