13. Anticoagulant therapy

Question 1

what are rivaroxaban, apixaban?

Answer 1

DOAC's 
directly inhibits factor Xa 
preferred long-term drug of choice
better than warfarin in preventing recurrent VTE  
*doesn't require lab monitoring

Question 2

when to consider giving fondaparinux

Answer 2

for HIT

Question 3

enoxaparin

Answer 3

LMWH
> UFH, except in renal failure, extreme obesity or hemodynamic instability

theraputic enoxaparin= 1.5mg/kg/day
prophylactic = 40mg/day