Inflammatory Bowel Disease

Question 1

Major features of:
- Crohns
- Ulcerative colitis

Answer 1

CROHNS
- Patchy (Skip lesions)
- Transmural
- Any part of GI tract (ileum common)
- High incidence of GI Cx: fistulas, abscesses, strictures, perianal disease

ULCERATIVE COLITIS
- Continuous
- Mucosal only
- Only colonic
- PR bleed common
—> thumb printing, lead pipe

Question 2

Complications of IBD:

Answer 2

Diarrhoea
Malabsorption

Abscess
Fistula
Perforation
Stricture
Perianal disease
—> Crohns

Toxic mega colon
—> UC

Complications of therapy:
- Steroids
- Azathiprine, mercaptopurine
- MTX
- Cyclosporin, tacrolimus
- ‘MABs