Procarbazine

Question 1

Chemical Class of Procarbazine

Answer 1

Methyl Hydrazine….

Question 2

Two metabolites of Procarbazine

Answer 2

Azo- Procarbazine - Methylate DNA
Weak mono amine oxidase inhibitor..

Question 3

MOA of Procarbazine

Answer 3

Chromosomal damage, Chromatid breaks and translocations…

Question 4

Use of Procarbazine as a drug

Answer 4

MOPP for Hodgkin’s and non Hodgkin’s lymphoma and brain tumor

Question 5

Contraindications of Procarbazine

Answer 5

Sympathomimetic, CNS depressents , anti diabetic, MAO INHIBITORS, Alcohol, antihistamines, antidepressants, tyramine containing food ..

Question 6

Major toxic effect of Procarbazine

Answer 6

Thrombocytopenia

Question 7

3 Platinum Compounds

Answer 7

Cisplatin - Divalent - Carboplatin
Oxaliplatin - tetravalent

Question 8

Types of cancer treated with platinum compounds

Answer 8

Ovarian, head and neck, esophagus, bladder, lung, colon ..

Question 9

Draw structure of all 3 Platinum Compounds

Answer 9

..

Question 10

MOA of Platinum Compounds

Answer 10

Entry through CTR1 - their ligands are displaced by water molecules.
Resulting highly reactive drug reacts with nucleophilic site on DNA and Protein

Question 11

Two different reactions of platinum complexes

Answer 11

Electron rich sites such as Sulphydryl forming both intrastrand and inter strand cross links

Cross links between N7 of guanine on same strands…

Question 12

Other attacks of Cisplatin

Answer 12

Mitochondria - production of ROS
Destruction of lysosomes - lysosomal protease
Degradation of endoplasmic reticulum - deregulation of calcium

Question 13

How Cisplatin impacts other organelles

Answer 13

Forming adducts with functional groups on proteins, specially sulphur in cystine and methionine side chains

Question 14

How Cisplatin cures testicular cancer

Answer 14

Combination of Cisplatin with etoposide and bleomycin… And ifofamide or vinblastine

Question 15

How carcinoma of Ovary is treated

Answer 15

Cisplatin or Carboplatin with paclitaxel

Question 16

Cisplatin produce response in which other cancers

Answer 16

Head and neck, Cervix, bladder, anal and rectal, lung, endometrium, and neoplasms of childhood

Question 17

Cancers where Cisplatin is more effective than Carboplatin

Answer 17

Germ cells, head and neck , oesophageal

Question 18

Cancers where Cisplatin and Carboplatin are equally effective

Answer 18

Ovarian Cancer, non small cell lung cancer, extensive stage small cell lung cancer

Question 19

Drug of choice from Carboplatin and Cisplatin

Answer 19

Carboplatin

Question 20

Biggest SE of Oxaliplatin

Answer 20

Peripheral motor and sensory neuropathy

Question 21

Other toxicities of Procarbazine

Answer 21

Myelosuppression
Ototoxicity
Nephrotoxicity
Electrolyte imbalance