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Immunology and Inflammation > Lec 19 > Flashcards

Lec 19 Flashcards

1
Q

what enzyme(s) are inhibited by NSAIDs?

A

COX1 and COX2

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2
Q

what is Arachidonic acid?

A

an eicosanoid which is the precursor to prostaglandins, leukotrienes, lipoxins, and epi-lipoxins

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3
Q

prostaglandins and leukotrienes are responsible for ____ of inflammation

A

initiation

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4
Q

lipoxins and 15-epi-lipoxins are responsible for ____ of inflammation

A

resolution

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5
Q

what enzyme(s) are inhibited by aspirin?

A

COX2

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6
Q

Arachidonic acid’s role in initiation is ___-inflammatory, whereas its role in resolution is ___-inflammatory

A

pro

anti

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7
Q

what three classes of enzymes produce eicosanoids?

A

cyclooxygenases, lipoxygenases, and cytochrome P450

epoxygenases

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8
Q

Arachidonic acid is one of the key precursor ____ _____ involved in the biosynthesis of _____ ______.

A

fatty acids

lipid mediators.

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9
Q

T/F Arachidonic acid is an essential fatty acid synthesized in mammals

A

False, it is an essential fatty acid that cannot be synthesized in mammals

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10
Q

Arachidonic acid is a major component of ______, so that it is important for the integrity of cellular membranes.

A

phospholipids

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11
Q

what does Arachidonic acid regulate which may be important in animal tissues?

A

apoptosis

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12
Q

T/F The stereochemistry of eicosanoids is not important for their biological function.

A

False, it is important

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13
Q

what enzyme is responsible for the release of

Arachidonic Acid from membrane lipids?

A

Phospholipase A2

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14
Q

what does TXA2 do?

A

vasoconstriction and platelet formation

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15
Q

what does PGD2 do?

A

erythema, edema, pain, and decrease platelet formation

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16
Q

what does PGE2 do?

A

erythema, edema, pain, and fever

17
Q

what does PGF2 do?

A

vasoconstriction

18
Q

what does PGI2 do?

A

vasodilation and decrease platelet formation

19
Q

which of the prostaglandins does misoprostol act like?

what does it do?

A

PGE1

induces labor

20
Q

which prostaglandin receptor does alprostadil bind to?

what does it treat?

A

PGE1

E.D.

21
Q

which prostaglandin receptor does dinoprostone bind to?

what does it do?

A

PGE2

induces abortion

22
Q

which prostaglandin receptor does carboprost bind to?

what does it do?

A

PGF2

reduces postpartum hemorrhage and induces abortion

23
Q

which of the prostaglandins does latanoprost act like?

what does it do?

A

PGF2

causes vasoconstriction in eyes

24
Q

which prostaglandin receptor does epoprostenol bind to?

what does it do?

A

PGI2

dec platelet aggregation

25
Q

flufenisal and diflunisal:

what are they?

A

NSAIDs

26
Q 
what drug class are mesalamine, sulfasalazine, and olsalazine?
what are they used for?
A

salicylate

inflammatory bowel disease

27
Q

what is indomethacin used for?

A

anti-inflamm/antipyretic

28
Q

what is sulindac?

what is its relationship to arachidonic acid?

A

an arylacetic acid

competes with arachidonic acid at active site of COX

29
Q

ketorolac is more potent as an? with minor?

has a high affinity for?

A

analgesic, anti-inflamm

COX1

30
Q

tolmetin has a high affinity for?

A

COX1

31
Q

diclofenac and etodolac bind to COX1 or COX2?

A

COX2

32
Q

ibuprofen, naproxen, fenoprofen, ketoprofen, and flurbiprofen are all ____ acid analogs

A

arylpropionic

33
Q

mefenamic acid, flufenamic acid, and meclofenamic acid are all what type of acid?
they are stronger than what drug?

A

anthranilic acid

aspirin

34
Q

acetaminophen may act on COX3 in the?

A

CNS

35
Q

what does Zileuton do?

what does it treat?

A

inhibits 5-lipoxygenase that converts arachidonic acid

chronic asthma

36
Q

zafirleukast is used for?

A

chronic asthma

37
Q

Montelukast is used for?

A

chronic asthma and allergic rhinitis

Immunology and Inflammation (12 decks)

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